Mechanistic Target of Rapamycin (mTOR) in the Cancer Setting

Mechanistic target of rapamycin (mTOR): A mediator of social development.

One of the great challenges facing developmental neuroscience is to understand how complex social interactions can shape brain development during ontogeny to affect adult functioning in social and behavioral contexts (1). Some of the most vexing behavioral problems, such as autism spectrum disorder that involves impaired social interactions, including verbal and nonverbal communication capabili...

Oncogenic Signalling through Mechanistic Target of Rapamycin (mTOR): A Driver of Metabolic Transformation and Cancer Progression

Throughout the years, research into signalling pathways involved in cancer progression has led to many discoveries of which mechanistic target of rapamycin (mTOR) is a key player. mTOR is a master regulator of cell growth control. mTOR is historically known to promote cell growth by enhancing the efficiency of protein translation. Research in the last decade has revealed that mTOR's role in pro...

The Role of Mechanistic Target of Rapamycin (mTOR) Complexes Signaling in the Immune Responses

The mechanistic Target of Rapamycin (mTOR) is an evolutionarily conserved serine/threonine kinase which is a member of the PI3K related kinase (PIKK) family. mTOR emerged as a central node in cellular metabolism, cell growth, and differentiation, as well as cancer metabolism. mTOR senses the nutrients, energy, insulin, growth factors, and environmental cues and transmits signals to downstream t...

Mechanistic Target of Rapamycin Inhibition

Mechanistic Target of Rapamycin Complex